Microdosing means using a low, steady dose of a GLP-1 medication for gentle support, rather than stepping up to a high target. This page is a plain-language reference for what the gentle approach looks like across tirzepatide and semaglutide.
One important note before the chart: dosing is always set by your provider. This is a reference for understanding the options, not a protocol to follow on your own. A microdose program stays in the gentle range and does not titrate up; a full-dose program steps up over time.
The full comparison at a glance
Here is how the two gentle microdose options compare to each other, and how both stack up against a full-dose GLP-1 program, across mechanism, dosing, focus, and price.
| Microdose Semaglutide | Microdose Tirzepatide | Full-Dose Semaglutide | Full-Dose Tirzepatide | |
|---|---|---|---|---|
| How it works | GLP-1 | Dual GIP + GLP-1 | GLP-1 | Dual GIP + GLP-1 |
| Approach | Gentle, mindful | Gentle, mindful | Full therapeutic | Full therapeutic |
| Dose | 0.25 mg, fixed | 2.5 mg, fixed | Starts 0.25 mg, titrates up | Starts 2.5 mg, titrates up |
| Titration | None, stays low | None, stays low | Steps up over time | Steps up over time |
| Frequency | Once weekly | Once weekly | Once weekly | Once weekly |
| Focus | Mindful eating, gentle cosmetic support | Mindful eating, gentle cosmetic support | Appetite regulation, metabolic goals | Appetite regulation, metabolic goals |
| What to expect | Subtle, gradual support | Subtle, gradual support | More pronounced appetite effect | More pronounced appetite effect |
| Async care messaging | Included | Included | Included | Included |
| Price (28-day supply) | $179 | $269 | $219 | $339 |
How to read this
The two microdose columns are the gentle lane: a single low dose, held steady, built around mindful eating. The two full-dose columns are the therapeutic lane, starting low and titrating up over time toward stronger appetite regulation. Neither lane is better than the other. They are built for different goals.
The other difference worth noting is mechanism. Semaglutide works on the GLP-1 pathway. Tirzepatide works on two pathways, GIP and GLP-1, which is why people sometimes respond differently to each.
Because everyone responds differently, your provider decides what is right for you. Two people on the same program may not be on identical plans.
How the Fitish program is structured
You begin with an online visit. A licensed provider reviews your information and, if the gentle approach is appropriate, sets your plan. The microdose lane is built to stay gentle rather than ramp up, and async messaging with the care team is included for Fitish patients, so questions between doses do not have to wait.
Microdose pricing at Fitish: tirzepatide $269, semaglutide $179.
For the full picture on each medication, see microdosing tirzepatide and microdosing semaglutide.
Common questions
What is a GLP-1 microdosing chart?
It is a side-by-side reference for what gentle, low-dose GLP-1 support looks like across semaglutide and tirzepatide, and how both compare to a full-dose program on mechanism, dose, titration, frequency, focus, and price. It is for understanding the options, not a protocol to follow on your own.
What is the dose for microdosing tirzepatide?
Fitish microdose tirzepatide is 2.5 mg once weekly, the lowest dose offering. It stays at that gentle level rather than climbing.
How much tirzepatide is used for microdosing?
The microdose is 2.5 mg, the lowest offering, taken once weekly and directed by your provider.
How many units is a microdose of semaglutide?
Fitish microdose semaglutide is 0.25 mg once weekly, the lowest dose offering. Exact unit markings depend on your specific compound, so follow your provider's direction.
Does microdosing titrate up over time?
No. The gentle approach is designed to stay in the low-dose range rather than climb to a maximum.
How much does GLP-1 microdosing cost at Fitish?
Microdose semaglutide is $179 and microdose tirzepatide is $269 for a 28-day supply, with async care-team messaging included rather than billed separately.